製品情報

English Name: Calcifediol Anhydrous

他の名前

25-Hydroxyvitamin D₃

25-Hydroxycholecalciferol

CAS Number: 19356-17-3

分子式C₂₇H₄₄O₂

Molecular Weight: 400.64

Purity: ≥98% (HPLC)

ブランド上海BBL

Appearance: White to pale yellow crystalline solid

Storage: -20°C, protected from light

溶解性：

Freely soluble in ethanol, ethyl acetate, chloroform, and diethyl ether

Soluble in DMSO (approximately 10 mg/ml) and DMF (approximately 10 mg/ml)

Solubility in 1:2 ethanol:PBS (pH 7.2): approximately 0.3 mg/ml

化学的性質

Particle Acidity (pKa): 14.74 ± 0.20 (predicted)

Stability: Light- and heat-sensitive, requires storage in dark and at low temperatures.

Appearance: White to pale yellow crystalline solid

Biological Source: Synthetic

作用メカニズム

Calcifediol anhydrous primarily binds to the vitamin D receptor (VDR), activating downstream signaling pathways, thereby exerting its effects on calcium and phosphorus metabolism and bone health. It is the primary metabolite of vitamin D₃ in the liver and is further converted to its active form, calcitriol (1,25-dihydroxyvitamin D₃), in the kidneys. This calcitriol regulates intestinal absorption of calcium and phosphorus, maintaining stable blood calcium and phosphorus levels.

Medical Applications

Osteoporosis: Used for the prevention and treatment of osteoporosis, increasing bone density, and reducing the risk of fractures.

Rickets and Osteomalacia: Used for the prevention and treatment of rickets in children and rickets in adults, promoting normal bone development and mineralization.

Other Diseases: Shows potential benefits in the prevention and treatment of certain autoimmune diseases, cardiovascular diseases, and certain cancers.

Packaging and Pricing

Packaging Specifications:

10mg, 100mg, 1kg

Price: Prices vary depending on the specific packaging; please inquire for details.

Calcifediol anhydrous is an important vitamin D₃ metabolite with multiple physiological functions, including regulating calcium and phosphorus metabolism, immune regulation, and promoting cell differentiation. It plays an important role in the prevention and treatment of diseases such as osteoporosis and rickets. With the advancement of biosynthesis technology, green and safe production methods are being continuously optimized, opening up new possibilities for the widespread application of calcifediol anhydrous.